Epidermolysis Bullosa: Soothing Skin with Cannabis

Epidermolysis Bullosa (EB) is a group of rare diseases that cause fragile, blistering skin. The condition can be painful and often leads to significant complications. Patients with EB have skin so delicate that even minor friction can cause blisters. As a result, finding gentle yet effective treatments to manage pain and inflammation is critical. Cannabis-infused topical products have emerged as a potential soothing agent for individuals living with EB due to their anti-inflammatory and pain-relieving properties.

Understanding Epidermolysis Bullosa

EB is not one disease but a complex family of disorders characterized by the skin’s inability to resist mechanical stresses, leading to blister formation from minor trauma. Traditional treatment focuses on wound care, pain management, and preventing complications, which can often involve frequent hospital visits and a variety of medications.

Cannabis and the Skin

The skin contains a high amount of cannabinoid receptors, part of the endocannabinoid system (ECS). The ECS plays a crucial role in maintaining skin integrity and function. Cannabinoids, like CBD (cannabidiol) and THC (tetrahydrocannabinol), can engage these receptors to mediate pain and inflammatory responses.

Topical Cannabis for EB

Cannabis-infused topical products, such as creams, ointments, and balms, are designed to be applied directly to the skin. They provide localized relief without the psychoactive effects typically associated with cannabis. This quality is particularly advantageous for EB patients who require frequent application to affected areas without impacting their cognitive function.

A review of studies published in the “Journal of the American Academy of Dermatology” suggests that cannabinoids may soothe the skin by reducing inflammation and pain, although it also calls for more research (Eagleston et al., 2018). These anti-inflammatory properties can be attributed to the suppression of cytokine production and the inhibition of cell proliferation by cannabinoids, mechanisms that are beneficial in treating inflammatory skin conditions.

Clinical Evidence

In clinical settings, some reports highlight the positive outcomes of cannabis-based treatments in EB patients. For instance, anecdotal evidence and case reports have suggested that the use of topical cannabis can significantly reduce pain and blistering while improving wound healing (Chelliah et al., 2018).

A case study presented in the journal “Pediatric Dermatology” showed that topical cannabinoid oil could decrease pain and the formation of blisters in a child with EB (Sheriff et al., 2020). This promising result indicates that cannabinoid-infused topical applications might play a role in the management of EB symptoms.

Safety and Considerations

While the use of cannabis-infused products for EB shows potential, it’s important for patients and caregivers to understand that these treatments should be part of a comprehensive care plan under the guidance of healthcare professionals. Furthermore, the purity and concentration of cannabinoids in topical products can vary greatly, making it essential to use products that are accurately labeled and third-party tested.


Cannabis-infused topical products present a promising addition to the management of Epidermolysis Bullosa. They offer the potential to soothe painful symptoms and improve the quality of life for those affected by this condition. However, as with any emerging treatment, further research and clinical trials are necessary to fully establish their efficacy and safety profile.


  1. Eagleston, L. R. M., Kalani, N. K., Patel, R. R., Flaten, H. K., Dunnick, C. A., & Dellavalle, R. P. (2018). Cannabinoids in dermatology: a scoping review. Journal of the American Academy of Dermatology, 78(6), 1205-1212.e4.
  2. Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. C. (2018). Self-initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric Dermatology, 35(4), e224–e227.
  3. Sheriff, T., Lin, M. J., Dubin, D., & Khorasani, H. (2020). The potential role of cannabinoids in dermatology. Journal of Dermatological Treatment, 31(8), 839-845.

This blog post is for informational purposes only and does not constitute medical advice. Patients with Epidermolysis Bullosa considering the use of medical cannabis should consult with their healthcare provider to ensure an integrated and safe approach to managing their condition.


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