Mitochondrial Disease: Can Cannabis Energize Cell Function?

Mitochondrial diseases are a group of disorders caused by dysfunctional mitochondria, the organelles that are the powerhouse of the cell. These diseases can result in a variety of symptoms, with one common factor being compromised energy production at the cellular level. As researchers seek innovative treatments to support individuals with mitochondrial diseases, there’s burgeoning interest in the potential role of cannabis, specifically the cannabinoids found within the plant, to support cellular energy production.

Understanding Mitochondrial Dysfunction

Mitochondria are responsible for producing more than 90% of the energy needed by the body to sustain life and support organ function. When these mitochondria are not working correctly, cells can’t get enough energy, leading to a range of symptoms and, in many cases, chronic and progressive illness. Mitochondrial diseases can affect almost any part of the body, including the muscles, brain, and heart.

Cannabis and Cellular Energy

The relationship between cannabis and mitochondrial function is an area of scientific curiosity. Cannabinoids such as THC and CBD interact with the endocannabinoid system, which plays a role in maintaining homeostasis in the body, including energy balance.

Research, including studies published in the journal Biochemical Pharmacology, suggests that cannabinoids can influence mitochondrial activity. For example, a 2016 study indicated that the endocannabinoid system is involved in the regulation of mitochondrial activity and energy production (Silvestri & Di Marzo, 2016). Cannabinoids have been found to impact the expression of genes and proteins that are key in maintaining the efficiency of the mitochondria.

Theoretical Potential of Cannabis in Mitochondrial Disease

The interaction between cannabinoids and mitochondria offers a theoretical potential for the treatment of mitochondrial diseases. By potentially enhancing mitochondrial function and energy production, cannabis could offer symptomatic relief. Some preclinical studies suggest that the neuroprotective and anti-inflammatory properties of cannabinoids might also support individuals with mitochondrial dysfunction.

Anecdotal Evidence and Patient Perspectives

While rigorous clinical data is sparse, there is anecdotal evidence from patients who report improved energy levels and overall well-being after using cannabis. These individual reports contribute to the call for more structured research on cannabis as a potential supportive therapy for mitochondrial diseases.

A Word of Caution

Despite the potential and the growing interest, it is essential to note that research in this area is still in its early stages. The use of cannabis to energize cell function in mitochondrial disease remains theoretical and should not replace conventional treatments. Cannabis is also known to have psychoactive effects and can interact with other medications, which could be particularly significant in individuals with complex medical conditions like mitochondrial diseases.


While the idea that cannabis could play a role in supporting cellular energy production is intriguing, much remains to be learned about its efficacy and safety in the context of mitochondrial diseases. The unique nature of these diseases calls for personalized medical approaches and careful consideration of any new therapies. Researchers continue to explore the full potential of cannabis, but until more data is available, it should be approached with caution.


  1. Silvestri, C., & Di Marzo, V. (2016). The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell Metabolism, 17(4), 475-490.
  2. Biochemical Pharmacology. (Various Issues). Retrieved from: [Link to journal’s homepage].

This article is for informational purposes only and should not be taken as medical advice. Individuals with mitochondrial disease should consult with their healthcare providers before considering any form of cannabis-based treatment.

Please note that access to full-text articles from the journal Biochemical Pharmacology typically requires a subscription or institutional access. However, summaries or abstracts of the research papers may be available online for the public. For comprehensive understanding and latest findings, medical professionals and researchers should refer to the original published research articles.