Peripheral Neuropathy: Numbing the Pain with Cannabis

Peripheral neuropathy is a condition characterized by damage to the body’s peripheral nerves, which often results in pain, tingling, and burning sensations, primarily in the hands and feet. Traditional treatments include a variety of medications, from pain relievers to anticonvulsants and antidepressants. However, as these can have limited effectiveness and various side effects, some patients and researchers are looking toward cannabis as a potential alternative or adjunct therapy.

Understanding Peripheral Neuropathy

Peripheral neuropathy can stem from traumatic injuries, infections, metabolic problems, inherited causes, and exposure to toxins. One of the most common causes is diabetes. The pain associated with peripheral neuropathy can be particularly debilitating because the nerve fibers themselves are damaged, sending incorrect signals to pain centers.

Cannabis as a Therapeutic Agent

Cannabis contains active compounds known as cannabinoids, which include THC (tetrahydrocannabinol) and CBD (cannabidiol). These compounds interact with the body’s endocannabinoid system (ECS), which plays a key role in regulating pain, among other functions.

Evidence Supporting Cannabis for Neuropathic Pain

A study published in the journal “Neurotherapeutics” highlighted that certain cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (Xiong et al., 2012). Another study in “The Journal of Pain” reported that patients who were treated with inhaled cannabis experienced a significant reduction in neuropathic pain (Wilsey et al., 2013).

In a meta-analysis and systematic review conducted by the “Harvard-led Multidisciplinary Association for Psychedelic Studies”, researchers found substantial evidence that cannabis is an effective treatment for chronic pain in adults, which would include neuropathic pain (Andreae et al., 2015).

Mechanism of Action

While the exact mechanisms by which cannabis compounds alleviate neuropathic pain are not fully understood, it’s believed that both THC and CBD may help by reducing the body’s inflammatory response and by modulating pain signaling pathways. THC binds to cannabinoid receptors in the brain and nervous system, potentially altering the perception of pain. CBD, while not binding directly to these receptors, is thought to work by influencing other components of the ECS.

Topical and Systemic Applications

Cannabis can be administered in various forms, including oral and topical applications. Topical cannabis, in the form of creams or ointments, can be applied directly to the affected area, providing localized relief without the psychoactive effects. For systemic symptoms, inhaled or ingested cannabis may offer broader pain relief.

Safety and Side Effects

Although cannabis is generally considered safe, it is not without potential side effects, particularly when it comes to THC-containing products. These can include dizziness, dry mouth, and in some cases, anxiety or paranoia. For this reason, starting with low doses and gradually increasing as needed is recommended.


Current research provides promising evidence for the use of cannabis in the treatment of neuropathic pain associated with peripheral neuropathy. The analgesic properties of cannabinoids may offer relief for those who have not found respite through conventional treatments. However, it is essential for patients to consult with healthcare professionals to tailor a treatment plan to their specific needs and to remain compliant with local laws regarding cannabis use.


  1. Xiong, W., Cui, T., Cheng, K., et al. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Neurotherapeutics.
  2. Wilsey, B., Marcotte, T., Tsodikov, A., et al. (2013). A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain. The Journal of Pain.
  3. Andreae, M. H., Carter, G. M., Shaparin, N., et al. (2015). Inhaled cannabis for chronic neuropathic pain: A meta-analysis of individual patient data. The Journal of Pain.

This content is for informational purposes only and does not constitute medical advice. It is crucial for patients to consult with their healthcare provider before beginning any new treatment, including medical cannabis, to ensure it is safe and appropriate for their specific condition.